Fat loss (GH fragment)
AOD-9604
Failed obesity trials; not approvedSmall human studiesAODhGH fragment 176-191
A modified piece of the end of growth hormone, designed to keep GH's fat-burning effect without raising IGF-1 or blood sugar. It was tested for obesity in human trials in the 2000s, including a 500-person trial, and didn't produce meaningful weight loss compared with placebo, so development stopped.
- Canada
- Not authorized
- United States
- Not approved as a drug
Download profile Opens in Vialchemy on your iPhone, where it's added to your Library as your own.
Not medical advice — talk to your doctor before making medical decisions.
At a glance
- Class
- GH fragment
- Mechanism
- Proposed: fat breakdown without raising IGF-1
- Evidence
- Human trials, negative for weight loss
- Canada
- Not authorized
- Us
- Not approved
- Half Life
- Short
- Routes
- SubQ
- Common Side Effects
- Generally well tolerated in trials; headache
- Key Cautions
- Didn't work for weight loss in trials; WADA prohibited
- Trial Weight Loss
- No meaningful difference vs placebo
What the research says
Does it cause fat loss?
Human trials didn't show meaningful weight loss compared with placebo, which is why it was abandoned as an obesity drug.
Is it safe?
It was reasonably well tolerated in trials, and it doesn't appear to raise IGF-1 or blood sugar.
If you're drug-tested in sport?
Prohibited by WADA (S2, growth hormone fragments).
Get medical care if
- Redness, heat, swelling or pus at a site that spreads or comes with fever
- Hives, swelling of the face or throat, or trouble breathing (call 911)
Buying and quality
- Not authorized by Health Canada. Products sold online as "research use only" are illegal to sell for human use in Canada, and the label doesn't change that.
- Health Canada warns these products may contain too much, too little or none of the peptide, plus contaminants like endotoxins, solvents, heavy metals or bacteria.
- A certificate of analysis (COA) from the seller isn't independent proof. A 98% purity result still leaves 2% unidentified.
- If you use it anyway: one clean needle per injection, sterile technique, label and date every vial, and stop if a site gets hot, red and spreading.
Dose calculator
Doses are set with your prescriber. This converts a dose you already have into what to draw; it doesn't recommend one. Check every number against your syringe and your vial's label.
Doses left in the vial
A blend vial
Not medical advice — talk to your doctor before making medical decisions.
Sources
Researched 2026-10-27. Trial results and approval status change.
General education, not medical advice. Nothing here is a dose recommendation. Doses, schedules and changes are set with a prescriber.